Results 41 to 50 of about 1,159,389 (274)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PENGARUH PERBANDINGAN CMC-NA, KARBOMER DAN TRAGAKAN SEBAGAI SUSPENDING AGENT TERHADAP SIFAT FISIK SUSPENSI PIRANTEL PAMOAT

, 2014
Suspensi adalah sediaan yang mengandung bahan obat padat dalam bentuk halus dan tidak larut, terdispersi dalam cairan pembawa. Masalah dalam penelitian ini adalah adakah pengaruh CMC-Na, karbomer, tragakan sebagai suspending agent dan manakah yang paling
Ade, Bagus
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

PEMANFAATAN PATI PISANG KEPOK (Musa balbisiana L.) TERPRAGELATINASI POSPAT SEBAGAI SUSPENDING AGENT SUSPENSI KLORAMFENIKOL

JIIS: Jurnal Ilmiah Ibnu Sina, 2023
Pati alami pisang kepok (Musa balbisiana L.) mudah sekali mengalami sineresis akibat terjadinya retrogradasi pati yang dapat menurunkan stabilitas dan viskositas dari suatu sediaan suspensi, sehingga perlu adanya modifikasi pati untuk mengatasi masalah ...
Deni Anggraini, Anita Lukman, Delvi
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

FORMULASI PATI UMBI PORANG (Amorphophallus muelleri) SEBAGAI SUSPENDING AGENT DALAM SUSPENSI PARASETAMOL [PDF]

, 2022
Parasetamol adalah obat analgesik antipiretik yang sangat banyak digunakan. Parasetamol memiliki rasa yang pahit dan sukar larut sehingga dapat dibuat dalam sediaan suspensi sehingga mudah diberikan kepada pasien yang mengalami kesulitan untuk menelan ...
MARISKA, MARISKA
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Evaluation of curculigo orchioides mucilage as suspending agent [PDF]

, 2011
Plant products served as an alternative to synthetic products because of local accessibility, eco friendly\ud nature and lower prices compared to imported synthetic products.
Gaikar, Nilesh
core  

PENGARUH PERBANDINGAN KADAR CMC Na SEBAGAI SUSPENDING AGENT TERHADAP SIFAT FISIK SUSPENSI ANTASIDA

, 2014
Penyakit maag merupakan kondisi yang sangat mengganggu aktivitas bila tidak ditangani dengan tepat dan dapat berakibat fatal. Masalah penelitian ini adalah : Adakah pengaruh penggunaan CMC Na sebagai suspending agent terhadap sifat fisik suspensi ...
., Ivalia
core   +1 more source