Results 31 to 40 of about 1,178,909 (237)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Procedimiento para obtener extracto de pulpo, el producto obtenido y su aplicación como suplemento para el cultivo y criopreservación de tejido y de células en suspensión de invertebrados marinos [PDF]

open access: yes, 2016
Número de publicación: ES2261054 A1 (01.11.2006) También publicado como: ES2261054 B1 (16.11.2007) Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.)P200403171 (31.12.2004)Extracto de pulpo como suplemento para el cultivo y criopreservación ...
Belarbi, El-Hassan   +6 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Administrative Sanctioning Regime for Gatekeepers: Consequences for Non-Compliance with the Digital Markets Act

open access: yesRevista Digital de Derecho Administrativo, 2023
El objetivo principal del presente estudio de investigación consiste en ofrecer un análisis sistemático del régimen administrativo sancionador que recae sobre grandes plataformas digitales, en cuanto superintermediadores con poder de alterar los ...
Juan Francisco Rodríguez Ayuso
doaj   +1 more source

Propuesta de un modelo de suspensión hindlimb para generar atrofia muscular en las extremidades posteriores de la rata [PDF]

open access: yes, 2012
61 p.La suspensión Hindlimb, es el modelo de atrofia muscular inducido por descarga más utilizado, propuesto en el año 2002 por Morey-Holton & Globus.
Arcos Alvear, Makarena   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Procedimiento de Obtención de un Material Cerámico de Forsterita [PDF]

open access: yes, 2016
Número de publicación: ES2345648 A1 (28.09.2010) También publicado como: ES2345648 B2 (21.07.2011 Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.) P200900844(27.03.2009)Procedimiento de obtención de un material cerámico de forsterita ...
Bono Barrón, Rafael   +4 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

EVALUACIÓN DE LAS PROPIEDADES REOLÓGICAS DE PASTAS DE AJONJOLÍ� ARTESANAL Y TECNIFICADA

open access: yesRevista U.D.C.A Actualidad & Divulgación Científica, 2013
Las pastas de ajonjolí son una suspensión coloidal compuesta, principalmente, de sólidos hidrófilos suspendidos en aceite. En este trabajo, se elaboraron dos tipos de pastas de ajonjolí: una por el método artesanal y la otra mediante una técnica ...
Diofanor Acevedo   +2 more
doaj  

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