Results 51 to 60 of about 1,163,025 (233)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Defence TechnologyStretchable microwave-absorbing metastructures (SMAMSs) that provide the ability to hide complex objects from radars have long been of interest. However, recent studies of SMAMSs have demonstrated the operating frequency can undergo alteration even at ...
Feihong Lin +6 more
doaj +1 more source
Method of the Metronidazole and Clotrimazole administration in the content of the emulsion basis
Zaporožskij Medicinskij Žurnal, 2013 Proved optimum method of administration of active pharmaceutical ingredients – metronidazole and clotrimazole – in the emulsion base of ointment as a suspension with vaseline oil.
V. V. Rudenko, S. V. Biryukova
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Addressing high rates of school suspension [PDF]
, 2012 This policy paper examines the impact of rising rates of school suspension on vulnerable children and young people. Often, the students suspended from school are those who can least afford to be absent from the classroom.
Toni Beauchamp
core
Research on Vision-Based Servoing and Trajectory Prediction Strategy for Capturing Illegal Drones
DronesA proposed strategy for managing airspace and preventing illegal drones from compromising security involves the use of autonomous drones equipped with three key functionalities.
Jinyu Ma +5 more
doaj +1 more source