Results 61 to 70 of about 1,163,025 (233)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Effect of Artificial Aging Conditions on Mechanical Properties of EN AW 6056 Aluminum Alloy
MetalsThe 6xxx series aluminum alloys are preferred in many industrial applications because they can achieve relatively high strength levels through heat treatment.
Gizem Ay +2 more
doaj +1 more source
Energies, 2020 Today, oil and gas fields gradually become mature with a high amount of water being produced (water cut (WC)), favoring conditions for gas hydrate formation up to the blockage of pipelines.
Trung-Kien Pham +4 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
IET Electric Power ApplicationsAiming at the problems of large normal force, large electromagnetic force pulsation and high cost of permanent magnet track of permanent magnet linear motor (PMLM), this paper proposes a novel double‐sided flux‐concentrating and stacked‐winding permanent
Ying Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Quantification and study of monthly variation of suspended sediment loads in Tafna basin – Algeria
Journal of Water and Land Development, 2018 The magnitude of the phenomenon is disproportionate in semi-arid or in temperate climates. Thus Algeria is one of the most affected countries by this phenomenon and its consequences.
Belarbi Fadila +3 more
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Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Journal of Water and Land Development, 2019 The purpose of the presented research is to analyse possible methods of thickening of the Microcystis aeruginosa (Kützing) Kützing cyanobacteria using the obtained concentrate as a biomass for the production of energy carriers and biologically valuable ...
Malovanyy Myroslav +5 more
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source