Results 61 to 70 of about 2,632,719 (335)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Prediction of Torque Arm Fatigue Life by Fuzzy Logic Method
Engineering ProceedingsIn this study, a fuzzy-logic-based decision support model is developed to predict the fatigue life of load-bearing system elements such as torque arm. Traditional methods for fatigue life prediction are mostly based on certain mathematical expressions ...
Caner Baybaş +2 more
doaj +1 more source
Research on recognition of ramp angle based on transducer
Journal of Hebei University of Science and Technology, 2015 Focusing on the recognition of ramp angle, the relationship between the signal of vehicle transducer and real ramp angle is studied. The force change of vehicle on the ramp, and the relationship between the body tilt angle and front and rear suspension ...
Wenhao GU +4 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Literature Review of Suspension Systems for Superconducting Elements
Machines, 2023 When designing suspension systems for superconducting elements, the primary challenge is to strike a balance between limiting the heat load to the cold mass and ensuring the proper mechanical resistance and/or stiffness of the system.
Luca Piacentini +5 more
doaj +1 more source
Articulated suspension system [PDF]
, 1989 The invention provides a rough terrain vehicle which maintains a substantially constant weight, and therefore traction, on all wheels, despite one wheel moving considerably higher or lower than the others, while avoiding a very soft spring suspension ...
Bickler, Donald B.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Micromachines, 2014 We present a comprehensive experimental investigation of a micromachined inductive suspension (MIS) based on 3D wire-bonded microcoils. A theoretical model has been developed to predict the levitation height of the disc-shaped proof mass (PM), which has ...
Zhiqiu Lu +3 more
doaj +1 more source
Impact of the COVID-19 pandemic on risk factors in residential projects
Journal of Asian Architecture and Building Engineering, 2023 The global economy was affected by the COVID-19 pandemic. This paper estimates the impact of the COVID-19 pandemic on the overall risk of construction projects in Egypt and identifies risk factors affected by the pandemic.
Mohamed Badawy +2 more
doaj +1 more source
Journal of Obstetrics and Gynaecology, 2003 The process by which senior hospital doctors are disciplined within the National Health Service is analysed. The mechanisms used are discussed and a number of faults are identified. Many of these faults give an unfair advantage to management and are contrary to the rules of 'Natural Justice'.
openaire +2 more sources