Results 91 to 100 of about 2,787,955 (300)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Declaração de Fortaleza Declaration of Fortaleza

Sustentabilidade em Debate, 2010
Declaração de FortalezaDeclaration of ...
2010 International Conference on Climate, Sustainability and Development in Semi-arid Regions
doaj  

A survey of Australian dairy farmers’ attitudes to their business, its challenges and transitioning to alternative enterprises

Scientific Reports
Dairy farmers are grappling with serious business challenges, including rising operational costs, labour shortages, unstable milk prices, changing consumer preferences, long hours with minimal downtime and unstable weather patterns due to climate change ...
Esra Celik, Diana Bogueva, Clive J.C. Phillips, Dora Marinova   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sustainability in Debate

Sustentabilidade em Debate, 2011
Sustainability in Debate
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The 4.2 ka event is not remarkable in the context of Holocene climate variability

Nature Communications
The “4.2 ka event” is a commonly described abrupt climate excursion that occurred about 4200 years ago. However, the extent to which this event is coherent across regional and larger scales is unclear.
Nicholas P. McKay, Darrell S. Kaufman, Stéphanie H. Arcusa, Hannah R. Kolus, David C. Edge, Michael P. Erb, Chris L. Hancock, Cody C. Routson, Maurycy Żarczyński, Leah P. Marshall, Georgia K. Roberts, Frank Telles   +11 more
doaj   +1 more source

An Assessment of the Impact of Climate Change on Human Health in New Hampshire [PDF]

, 2014
Climate change threatens human health in many ways. The negative impacts of climate change on human health are likely to increase in both magnitude and frequency as the climate continues to change in response to ever increasing global emissions of heat ...
Aytur, Semra, Bucci, John, Wake, Cameron P.   +2 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Declaração de Fortaleza

Sustentabilidade em Debate, 2010
Declaração de ...
2010 International Conference on Climate Sustainability and Development in Semi-arid Regions
doaj