Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
The feasibility of detecting trees affected by the pine wood nematode using remote sensing [PDF]
, 2015 Institute for Environment and Sustainability (Joint Research Centre)
core +1 more source
A tool for sustainability impact assessment (ToSIA)of forest-wood chains linked with a database of sustainability indicators collected within the EFORWOOD project [PDF]
, 2009 Within the EFORWOOD project new approaches to assess the sustainability impacts of forest-wood chains (FWC) using indicators of environmental, social and economic sustainability were ...
Cerny, Martin +10 more
core
Contextualizing Digital Innovation and Artificial Intelligence to Sustainable Development [PDF]
, 2021 Sunil Kumar Mishra, Parul Mishra
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Reviewing the 95 sociotechnical barriers to the decarbonization of buildings
Nature CommunicationsBuilding decarbonization is critical to meet climate goals, given the embodied energy, and material resources needed to construct buildings, their operational energy use, and the need for new facilities for growing populations in addition to retrofitting
Erin Heinz +3 more
doaj +1 more source
A Model for Implementing a Successful Sustainability Strategy [PDF]
, 2012 The process of implementing sustainability within national and international corporate functions requires senior management commitment and a sustainability team which employs the correct leadership knowledge and skills.
Brauer, David B
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source