Results 141 to 150 of about 1,657,321 (297)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Letter to Dr. Robert Peyton from Sustainability Council
, 1997 Sustainability Council of Ventura County write a letter to Dr. Robert Peyton, Academic Planner of CSU Channel Islands and suggest to integrate sustainable principles into the curriculum and on the physical ...
Chianese, Robert +1 more
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Sustaining the planet by sustaining ourselves
BJC ReportsThe author transitions his career in oncology to one in planetary health. The career pivot begins after he recognizes similarities between the pandemic and the climate crisis. The author determines that stepping away from his role as chair of radiology for a one-year sabbatical is the most efficient way to learn about sustainability.
openaire +3 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
John Robinson Presentation - Sport & sustainability: Universities as agents for change
, 2013 John Robinson - Professor & Associate Provost, UBC Sustainability - gives a video presentation for the Strategy and Engagement session of Think Tank 3 - Sport & Sustainability: Universities as Agents for Change. This event was hosted by the UBC Centre of
Robinson, John
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A Prescription for Program Sustainability: The Drug-Free Community Sustainability Model in Practice. [PDF]
J Public Health Manag PractMercer Kollar LM +7 more
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Climate change social research: summary of key findings
, 2017 With Sustainability Victoria’s (SV’s) refocus on supporting the community to act on climate change, the need for reliable intelligence on current community attitudes, beliefs, behaviours and expectations of government in the area of climate change ...
Sustainability Victoria
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