Results 121 to 130 of about 1,657,321 (297)

Susteinability in Debate

Sustentabilidade em Debate, 2012
Sustainability in Debate
doaj   +1 more source

Declaração de Fortaleza

Sustentabilidade em Debate, 2010
Declaração de ...
2010 International Conference on Climate Sustainability and Development in Semi-arid Regions
doaj  

Food for thought

EMBO Reports
Multi-criteria sustainability analyses, based on life cycle thinking and assessment, are critical to help us navigate sustainable transitions in food and agriculture.
Nathan Pelletier, Sofia Bahmutsky, Nicole Bamber, Jared Brown, Lauren McNeil, Nicole Sibanda, Shaiyan Siddique, Amandeep Singh, Ian Turner   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

ODOT sustainability plan and program update

, 2008
v. 1. Setting the context -- v. 2. Sustainability management framework for ODOT's internal operationsThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program.

core  

Full Journal

Sustentabilidade em Debate, 2013
Sustainability in Debate
doaj   +1 more source

High-ambition climate action in all sectors can achieve a 65% greenhouse gas emissions reduction in the United States by 2035

npj Climate Action
Under the next cycle of target setting under the Paris Agreement, countries will be updating and submitting new nationally determined contributions (NDCs) over the coming year.
Alicia Zhao, Kowan T. V. O’Keefe, Matthew Binsted, Haewon McJeon, Adriana Bryant, Claire Squire, Mengqi Zhang, Steven J. Smith, Ryna Cui, Yang Ou, Gokul Iyer, Shannon Kennedy, Nate Hultman   +12 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Sustainable or not sustainable?

Environmental degradation, scarcity of resources, and societal issues have been reshaping the strategic agendas and governance mechanisms of many organizations. From a traditional perspective, the duty of the board of directors (BOD) has always been to the owners and investors of the firm.
Chams, Nour||, García-Blandón, Josep
openaire   +1 more source