Results 61 to 70 of about 3,306,869 (332)

Selection of sustainability indicators for health services in challenging environments: balancing scientific approach with political engagement.

open access: yes, 2012
Sustainability evaluation has become a key component of international health. However, evaluators have faced a number of challenges linked to the lack of consensus on the meaning of the concept of "sustainability".
Blanchet, Karl, Girois, Susan
core   +1 more source

Sustainability Education and Learning Committee Web Portal [PDF]

open access: yes, 2020
Course Code: ENR/AEDE 4567This project was completed for The Sustainability Education and Learning Committee (SELC) of OSU's Sustainability Institute to provide insight and student perspective on the best way to design an interactive web portal that ...
Augenstein, Emily   +4 more
core  

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Linking concepts of change and ecosystem services research: A systematic review

open access: yesChange and Adaptation in Socio-Ecological Systems, 2018
Transformation, transition and regime shift are increasingly applied concepts in the academic literature to describe changes in society and the environment.
Rau Anna-Lena   +14 more
doaj   +1 more source

Sustainability marketing: a global perspektive : a book review [PDF]

open access: yes, 2015
Book review: Sustainability Marketing - A Global Perspective, Frank-Martin Belz, Ken Peattie, 2nd ed. Wiley, Chichester, West Sussex (2012). p. 336, ISBN 978-1-119-96619-7 (paperback) Frank-Martin Belz is Professor at the Technische Universität München ...
Ludorf, Sebastian   +1 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Trans-disciplinary Research: An Academic-Practitioner Partnership Effort on Investigating the Relationship between the Cooperative Model and Sustainability

open access: yesRIMCIS, 2015
This article details novel research methodology developed through a researcher-practitioner partnership and employed in a three-phase research effort that explored relationships between the co-operative model and sustainable development.
Robert Newell   +5 more
doaj   +1 more source

Sustainability Science for Strong Sustainability

open access: yes, 2014
The dynamism of science has been catalytic for human prosperity in recent history. Conventional perspectives of the ivory tower model of modern science are, however, rivalled by the failure of humanity to tackle global crises of an economic, environmental and social nature.
openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

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