Results 131 to 140 of about 292,782 (296)

On design-based empirical research and its interpretation and ethics in sustainability science. [PDF]

Proc Natl Acad Sci U S A, 2021
Barrett CB.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dynamic reciprocal contributions between Indigenous communities and cultural keystone species: A study case in Western Ecuador

People and Nature
The reciprocal contributions concept provides a holistic approach to understanding management of natural resources in social‐ecological systems. The purpose of this study was to understand how Indigenous peoples build reciprocal contributions with ...
Gabriela Loayza, Shirley Pozo, Max Lascano, Anne‐Gaël Bilhaut, Anita Krainer, Irene Teixidor‐Toneu, Rommel Montúfar   +6 more
doaj   +1 more source

Advancing Sustainability Through Land-Related Approaches: Insights from NRC (1999) and a Bold Call to Action

Land
This paper investigates the critical role of land in advancing sustainability, drawing insights from the landmark report by the U.S. National Research Council, Our Common Journey: A Transition Toward Sustainability (hereafter referred to as NRC (1999 ...
Bing-Bing Zhou, Jingyuan Liu, Xiaoke Wang   +2 more
doaj   +1 more source

A perspective on the role of uncertainty in sustainability science and engineering. [PDF]

Resour Conserv Recycl, 2021
Diwekar U, Amekudzi-Kennedy A, Bakshi B, Baumgartner R, Boumans R, Burger P, Cabezas H, Egler M, Farley J, Fath B, Gleason T, Huang Y, Karunanithi A, Khanna V, Mangan A, Mayer AL, Mukherjee R, Mullally G, Rico-Ramirez V, Shonnard D, Svanström M, Theis T.   +21 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Developing methods of knowledge co-production across varying contexts to shape Sustainability Science theory and practice. [PDF]

Sustain Sci, 2022
Maclean K, Greenaway A, Grünbühel C.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stakeholder engagement in participatory research in French marine and freshwater social‐ecological systems: A systematic map protocol

Ecological Solutions and Evidence
Stakeholder engagement (SkE) in research is currently experiencing significant growth within the fields of environmental and sustainability sciences.
Adrien Chevallier, Heikel Balti, Sophie Gourguet, Claire Macher, Yunne‐Jai Shin, Fabien Moullec   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source