Results 141 to 150 of about 1,366,775 (299)

Science for Place-based Socioecological Management: Lessons from the Maya Forest (Chiapas and Petén) [PDF]

open access: yes, 2006
The role humans should play in conservation is a pervasive issue of debate in environmental thinking. Two long-established poles of this debate can be identified on a preservation-sustainable use continuum. At one extreme are use bans and natural science-
Manuel-Navarrete, David   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Sustainability Science

open access: yes, 2021
Siirilä Jani   +3 more
openaire   +3 more sources

Commonwealth Fisheries Harvest Strategy: Policy and Guidelines [PDF]

open access: yes, 2007
The harvest strategy policy and associated implementation guidelines was developed by the Australian Government in 2007. The aim was to ensure that key commercial fish species are managed for long -- term biological sustainability and economic ...

core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Very short introduction to positional analysis [PDF]

open access: yes, 2019
Recurso pedagógico (uc 23002 e 43018)From a sustainability science perspective (Dedeurwaerdere 2014) and circular economy education (Kopnina 2018), an alternative to cost-benefit analysis is worth exploring. The opposition between cost-benefit analysis
Jacquinet, Marc
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

LEARNING SCIENCE ORIENTED PEDAGOGY FOR SUSTAINABILITY TO BUILD THE CONCERN FOR THE ENVIRONMENT [PDF]

open access: yes, 2014
This study aims to study the application of science teaching oriented pedagogy for sustainability. Until the era of the 21st century , human behavior to care about the environment has not been fully realized.
Susilowati, Susilowati
core  

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