Results 71 to 80 of about 1,366,775 (299)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sustainability dialogues in Brazil: implications for boundary-spanning science and education

Global Sustainability
Non-technical summary Brazil – one of the world's largest biocultural diversities – faces high rates of habitat loss, social inequality, and land conflicts impacting indigenous and local peoples.
Fabio R. Scarano, Ebba Brink, Beatriz L. R. Carneiro, Luciane Coutinho, Clemir Fernandes, Vitória L. Holz, Moema Salgado, Ana C. P. Aguiar, Agnieszka E. Latawiec, Renata Pardini, Michelle C. Sampaio, Anna C. F. Aguiar, Paulo D. Branco, Laísa Freire, Maíra C. G. Padgurschi, Aliny P. F. Pires, Isadora M. M. Soares, Alexandro Solórzano   +17 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Achieving the promise of integration in social-ecological research: a review and prospectus

Ecology and Society, 2018
An integrated understanding of both social and ecological aspects of environmental issues is essential to address pressing sustainability challenges. An integrated social-ecological systems perspective is purported to provide a better understanding of ...
Angela M. Guerrero, Nathan J. Bennett, Kerrie A. Wilson, Neil Carter, David Gill, Morena Mills, Christopher D. Ives, Matthew J. Selinske, Cecilia Larrosa, Sarah Bekessy, Fraser A. Januchowski-Hartley, Henry Travers, Carina A. Wyborn, Ana Nuno   +13 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Interlinking ecosystem services and Ostrom's framework through orientation in sustainability research

Ecology and Society, 2016
Structuring integrated social-ecological systems (SES) research remains a core challenge for achieving sustainability. Numerous concepts and frameworks exist, but there is a lack of mutual learning and orientation of knowledge between them.
Stefan Partelow, Klara J. Winkler
doaj   +1 more source

Analyzing a transition to a sustainability-oriented science system in Germany [PDF]

, 2012
The multi-level perspective has successfully been applied to the analysis of complex sector transitions in the energy, the health or the food production sector.
Augenstein, Karoline, Schneidewind, Uwe
core   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Integrated Risk Assessment for the Blue Economy

Frontiers in Marine Science, 2019
With the anticipated boom in the ‘blue economy’ and associated increases in industrialization across the world’s oceans, new and complex risks are being introduced to ocean ecosystems.
Emma E. Hodgson, Emma E. Hodgson, Timothy E. Essington, Jameal F. Samhouri, Edward H. Allison, Edward H. Allison, Nathan J. Bennett, Ann Bostrom, Alison C. Cullen, Stephen Kasperski, Phillip S. Levin, Melissa R. Poe, Melissa R. Poe   +12 more
doaj   +1 more source