Results 131 to 140 of about 3,310,090 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Economía social y solidaria y crisis ecosocial: la intercooperación como herramienta para avanzar en las transiciones

Revista Iberoamericana de Estudios de Desarrollo
In the current context of eco-social crisis, the capitalist system seems incapable of dealing with problems that it itself has generated. Therefore, the social and solidarity economy (SSE) can play an important role, by proposing to organize the economy ...
Aratz Soto-Gorrotxategi, Enekoitz Etxezarreta-Etxarri, Unai Villalba-Eguiluz   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Implementing the Adkar Change Management Model to Enhance Sustainability Transitions in Romanian Swine Farms

Agriculture
Romania faces a double challenge in the swine production sector. On one hand, the European Union’s environmental agenda demands that member states drastically reduce both the carbon footprint and the use of antibiotics in animal husbandry by 2030. On the
Florin Gheorghe Lup, Ramona Vasilica Bacter, Alina Emilia Maria Gherdan, Monica Angelica Dodu, Andra Lazar, Anca Chereji, Alexandra Ungureanu   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Sustainability Initiatives Conference Outline

, 2001
The outline is a concept for a Sustainability initiative conference that would allow interested parties to share their initiatives in the area of sustainability.
Sustainability Council of Venura County
core  

National development in post-revolutionary Egypt: sustainability through water megaprojects?

Frontiers in Water
Water management in Egypt faces an intricate challenge because the country heavily depends on its natural water ecosystem. Novel adaptation and mitigation measures are urgently needed, as competition for water has increased dramatically among ...
Ann-Katrin Ellermann, Johannes Hamhaber, Mohammad Al-Saidi   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Meta-organizations for Sustainability Transformations: Navigating Tensions Between Imperatives of Transition and Meta-organizationality

Journal of Organizational Sociology
How do we change social orders to deliver a sustainable future? A growing literature in organization studies argues that meta-organizations are part of the answer.
Berkowitz Heloise, Bor Sanne
doaj   +1 more source