Results 141 to 150 of about 3,310,090 (304)
Journal of Asia Entrepreneurship and SustainabilityThe increased pressure in the use of natural resources and the rising environmental issues have heightened the quest in finding a development model to support economic development and ecological consciousness.
Dr. Meghna Tiwari, Dr. Rakshita Puranik
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Education for sustainability in transition of children from early childood education to primary school [PDF]
, 2012 This study examined the understandings gained by young children from education for sustainability experiences in their early childhood education and their actions and behaviours related to sustainability in their later years.
Biss, Tracey Elizabeth
core
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Institute of Natural Resource Sustainability 2008-2009 Annual Report [PDF]
, 2009 not peer reviewedSubmitted by Susan Braxton (braxton@illinois.edu) on 2011-11-09T15:58:39Z No. of bitstreams: 1 annual-rept-fy09.pdf: 2063631 bytes, checksum: c9de98955cb7abde12830c64339933ff (MD5)Made available in DSpace on 2011-11-09T15:58:39Z (GMT ...
Institute of Natural Resource Sustainability
core
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Fiscal regime changes and the sustainability of fiscal imbalance in South Africa; a smooth transition error-correction approach [PDF]
In addition to the conventional linear cointegration test, this paper tests the asymmetry relationship between fiscal revenue and expenditure, by making a distinction between the adjustment of positive (budget surplus) and negative (budget deficit ...
Samuel S. Jibao +2 more
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Behaviour and the individual in sustainability transitions
This chapter explores the critical role of individual behaviour in sustainability transitions, a field that has traditionally focused more on macro-meso-level processes. While systemic changes in technology and policy are essential, the actions of individuals and small groups significantly influence the adoption of sustainable practices and the shaping
Elisabeth Dütschke +2 more
openaire +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source