Results 51 to 60 of about 25,118 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Contextualising a multi-dimensional perspective on energy poverty for South Africa’s just energy transition: a systematic literature review

Environmental Research: Energy
Energy poverty is a multifaceted and urgent issue in the Global South, especially in South Africa, where, despite an electrification rate exceeding 90%, a substantial 40% of the population still experiences energy poverty.
Thandeka Tshabalala, Megan Davies, Nthabiseng Mohlakoana   +2 more
doaj   +1 more source

Transdisciplinary curriculum design for sustainability transitions: A reflective dialogue

South African Journal of Science
Inter- and transdisciplinary curricula can potentially develop an integrated understanding of an increasingly interconnected, complex world and develop students’ agency, empathy, creativity and critical thinking skills.
Lausanne Olvitt, Megan Davies, A'ishah Ebrahim, Jessica Cockburn   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Exploring a Water–Energy–Food (WEF) Nexus Approach to Governance: A Case Study of the V&A Waterfront in Cape Town, South Africa

Energies
The water–energy–food (WEF) nexus is recognised globally as a framework for sustainable resource management and a potential tool for building resilient social-ecological systems (SES).
Lourens Swart, Mark Swilling, Amanda Gcanga   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Drivers of change in human–wildlife relationships: Southern Africa as an example

People and Nature
Human–wildlife relationships (HWRs) are changing globally in response to shifts in ecological dynamics and societal values, often resulting in contestation.
Dian Spear
doaj   +1 more source

Universities and Sustainable Development Goals localisation: insights from academic staff in Zimbabwe

Cogent Education
The year 2024 marked nine of the 15-year timeline towards attaining the Sustainable Development Goals (SDGs). Consequently, questions arise regarding the progress made.
Godwell Nhamo, Lazarus Chapungu, Kaitano Dube   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Sustainability Transitions Research

Sustainability transitions research examines how societies can fundamentally transform their socio-technical systems toward collectively envisioned sustainable futures, which themselves are continuously negotiated and redefined. This chapter introduces key concepts, development, and significance of this emerging interdisciplinary field.
Abe Hendriks, Julius Wesche
openaire   +2 more sources