Results 131 to 140 of about 328,877 (308)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Bryophytes as a Sustainable Alternative for Period Products

open access: yesProceedings
Throughout history, bryophytes have been utilized in various contexts for their remarkable properties [...]
Laura Roxana Horvath   +3 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

SUSTAINABLE GROWTH IN AGRICULTURAL PRODUCTION: POETRY, POLICY AND SCIENCE

open access: yes
In this paper I review the evolution of the sustainability concept. This is followed by a description of three "classical" systems of sustainable agriculture. None of these systems were or are capable of generating growth of output consistent with modern
Ruttan, Vernon W.
core  

Strategies for sustainable alternative food networks in uncertain times

open access: yes, 2022
The traditional food supply chains are vulnerable to external shocks, and this has been observable during the pandemic. Alternative food networks (AFNs) is seen as a potentially viable alternative to traditional food supply chains.
Levinsohn, Duncan,   +3 more
core  

SUSTAINABLE BIOPLASTIC AS AN ALTERNATIVE TO DISPOSABLES

open access: yes
The project aims to develop biodegradable bioplastics made with natural, affordable, and sustainable raw materials, with the potential to replace conventional plastic products in everyday use. In recent years, plastic has been causing both environmental and human health problems, both during the production and consumption stages, and without post ...
Silva, Maria   +3 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Climate Change Strategy and Sustainable Power Technologies in China [PDF]

open access: yes
Global warming is likely to be the greatest environmental challenge among various known climate changes that related with many aspects of land use and water management in the 21st century.
Yoshiro Higano, Bin Li
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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