Results 91 to 100 of about 107,483 (315)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Effect of Visual Landscape Design on the Emotional and Physiological Responses of Older Adults

open access: yesBuildings
Landscape quality significantly impacts residents’ well-being through visual perception, particularly among the elderly who exhibit heightened sensitivity to environmental stimuli. Therefore, this study investigates how landscape configurations influence
Yalin Zhang   +4 more
doaj   +1 more source

Sustainable Architecture in Context

open access: yesScience & Technology Studies, 2008
There has been little emphasis in STS scholarship to date on the design of the built environment. This paper attempts to address this oversight by examining alternative design practices in the growing field of sustainable architecture. We propose a geohistorical framework that includes three design dispositions?"context-bound, context-free, and context-
Steven A. Moore, Andrew Karvonen
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Tensile architecture and sustainable approach [PDF]

open access: yes, 2019
The chapter deals with the subject of temporary architecture, which can be actually completed by means of various technologies, either sustainable or invasive, but eventually both with a short period of impact.
Francese Dora
core  

Climate-Based Assessment of Radiative Cooling Potential Using Energy Simulation and Atmospheric Indicators

open access: yesBuildings
Rising global temperatures are driving an urgent need for buildings that consume less energy while maintaining comfort. Cooling demand is surging worldwide, yet conventional air-conditioning remains energy-intensive and carbon-heavy.
Xiaolin Ding   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

SUSTAINABLE INNOVATIVE MATERIALS FOR INTERIOR ARCHITECTURE USING BIOMIMICRY

open access: yes, 2018
Over the years, man has been on a quest to discover solutions to challenges facing the world. Biomimicry is among the emerging discoveries which offer a lot of potential for solutions to world environmental challenges, especially in the area of ...
Sahraiyanjahromi, Faraneh, Lodson, Joyce
core   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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