Results 91 to 100 of about 4,166,525 (285)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Sustainable communities policy review : Stoke [PDF]

open access: yes, 2012
This report is part of the evidence base for 'In-depth review of sustainable communities policy'.This paper includes evidence collated from an Sustainable Development Commission visit, Audit Commission North Staffordshire Pathfinder report (2004) and ...
Sustainable Development Commission
core   +2 more sources

The Effect of Visual Landscape Design on the Emotional and Physiological Responses of Older Adults

open access: yesBuildings
Landscape quality significantly impacts residents’ well-being through visual perception, particularly among the elderly who exhibit heightened sensitivity to environmental stimuli. Therefore, this study investigates how landscape configurations influence
Yalin Zhang   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Public attitudes to sustainable development [PDF]

open access: yes, 2012
There is a lot of information around on public attitudes to sustainable development, with varying degrees of reliability and relevance. Most of the work referred to here is UK based and comes from DETR, the British Social Attitudes survey and MORI ...
Sustainable Development Commission
core   +2 more sources

Exploring biomimicry in agriculture focuses on how insights from natural systems can revolutionize farming practices and enhance food security [PDF]

open access: yesBIO Web of Conferences
Biomimicry, a design philosophy that is based on the principles of nature, presents a promising solution to the sustainability challenges faced by modern agriculture.
Othmani Nurul Izzati   +10 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Climate-Based Assessment of Radiative Cooling Potential Using Energy Simulation and Atmospheric Indicators

open access: yesBuildings
Rising global temperatures are driving an urgent need for buildings that consume less energy while maintaining comfort. Cooling demand is surging worldwide, yet conventional air-conditioning remains energy-intensive and carbon-heavy.
Xiaolin Ding   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

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