Results 81 to 90 of about 4,166,525 (285)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Systematic Review: Examining the Impacts of Artificial Intelligence

Journal of Artificial Intelligence in Architecture
Since its breakthrough in the mid-20th century, Artificial Intelligence (AI) has held great promises for improving the capacity of urban planning to address complex problems.
David Chow, Catharina Dwi Astuti Depari, Eva Gabriella   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Urban green spaces as a climate adaptation strategy. Case study in Geneva, Switzerland

City and Environment Interactions
In a context marked by the urgency of climate change, dwindling resources, and environmental crisis, concrete action towards ecological transition and climate adaptation is a top priority for urban areas.
Sophie Lufkin, Emmanuel Rey
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Upcycling Prefabricated Building Materials to Develop Pavilions for Community Gardens in Huddersfield, UK

Proceedings
As average temperatures in the UK continue to rise, and the effects of climate change are felt across communities, the government has revised requirements for urban development pertaining to Biodiversity Net Gain and access to green spaces (under the ...
Yun Gao, Manas Murthy, Tamiris Capellaro Ferreira, Nwakaego Onyenokporo, Hemen Galal, Nic Clear   +5 more
doaj   +1 more source

A sustainable material for sustainable architecture: wood in parasite architecture

Congresso Internacional sobre Patologia e Reabilitação das Construções, 2021
Rinaldi S., Frunzio G., Guadagnuolo M., Di Gennaro L., Massaro L.   +4 more
openaire   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Assessment of Health-Oriented Layout and Perceived Density in High-Density Public Residential Areas: A Case Study of Shenzhen

Buildings
Rapid urbanization has intensified public housing development and building density, posing significant challenges to residents’ well-being and urban sustainability. With the population of the Greater Bay Area on the rise, enhancing the spatial quality of
Guangxun Cui, Menghan Wang, Yue Fan, Fei Xue, Huanhui Chen   +4 more
doaj   +1 more source