Results 71 to 80 of about 4,416,693 (237)

The right ingredients : Sustainable Development Commission Scotland response to the discussion on a national food policy for Scotland [PDF]

open access: yes, 2012
Response of the Sustainable Development Commission Scotland to a consultation on national food policy for Scotland.Publisher ...
Sustainable Development Commission Scotland
core   +2 more sources

Spatial (in)justice shaping the home as a space of work

open access: yesBuildings & Cities
Drawing on an extensive literature review, this study examines how injustices manifest in space and the role of space in engendering injustices when associated with working at home.
Dalia Milián Bernal   +5 more
doaj   +1 more source

Architectural sustainability: A new inspiration [PDF]

open access: yesSAJ - Serbian Architectural Journal, 2016
Sustainable building, use of local materials, responsible use of soils, re-use, adaptability to climate, are all concepts that became worldwide part of the vocabulary of contemporary architectural design since the energy expenditure in the construction sector has proved to be of such magnitude to be unsustainable in the medium and long term.
openaire   +3 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Toward an A Priori Sustainable Architecture [PDF]

open access: yesArts, 2014
After decades of belief in the principles that man has absolute dominion over nature, and thus, in the separation of natural and anthropic processes, humanity is at the beginning of a new era characterized by the search for a renewed pact between man and the environment.
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A Study on the Effect of Dynamic Photovoltaic Shading Devices on Energy Consumption and Daylighting of an Office Building

open access: yesBuildings
Photovoltaic shading devices (PVSDs) have the dual function of providing shade and generating electricity, which can reduce building energy consumption and improve indoor daylighting levels.
Yan Jiang   +3 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

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