Results 61 to 70 of about 67,008 (267)

Impact of Thermal Mass, Window Performance, and Window–Wall Ratio on Indoor Thermal Dynamics in Public Buildings

open access: yesBuildings
Thermal comfort in public buildings is crucial for occupant well-being and energy efficiency. This study employs TRNSYS software to simulate the effects of thermal mass, window performance, and window–wall ratio (WWR) on summer thermal comfort.
Ran Cheng   +5 more
doaj   +1 more source

Carving Sustainability into Architecture Knowledge Practice

open access: yes, 2023
In the daily work of a software architect, knowledge is ubiquitous. In addition to technical expertise, architecture knowledge (AK) also requires practical experience in the representation, communication, and management of architectural decisions. However, there is a pressing need to also incorporate sustainability aspects, i.e., capturing decisions ...
Markus Funke, Patricia Lago
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Architectural sustainability: A new inspiration [PDF]

open access: yesSAJ - Serbian Architectural Journal, 2016
Sustainable building, use of local materials, responsible use of soils, re-use, adaptability to climate, are all concepts that became worldwide part of the vocabulary of contemporary architectural design since the energy expenditure in the construction sector has proved to be of such magnitude to be unsustainable in the medium and long term.
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Toward an A Priori Sustainable Architecture [PDF]

open access: yesArts, 2014
After decades of belief in the principles that man has absolute dominion over nature, and thus, in the separation of natural and anthropic processes, humanity is at the beginning of a new era characterized by the search for a renewed pact between man and the environment.
openaire   +3 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Spatial (in)justice shaping the home as a space of work

open access: yesBuildings & Cities
Drawing on an extensive literature review, this study examines how injustices manifest in space and the role of space in engendering injustices when associated with working at home.
Dalia Milián Bernal   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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