Results 81 to 90 of about 67,008 (267)

Urban green spaces as a climate adaptation strategy. Case study in Geneva, Switzerland

City and Environment Interactions
In a context marked by the urgency of climate change, dwindling resources, and environmental crisis, concrete action towards ecological transition and climate adaptation is a top priority for urban areas.
Sophie Lufkin, Emmanuel Rey
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Upcycling Prefabricated Building Materials to Develop Pavilions for Community Gardens in Huddersfield, UK

Proceedings
As average temperatures in the UK continue to rise, and the effects of climate change are felt across communities, the government has revised requirements for urban development pertaining to Biodiversity Net Gain and access to green spaces (under the ...
Yun Gao, Manas Murthy, Tamiris Capellaro Ferreira, Nwakaego Onyenokporo, Hemen Galal, Nic Clear   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A sustainable material for sustainable architecture: wood in parasite architecture

Congresso Internacional sobre Patologia e Reabilitação das Construções, 2021
Rinaldi S., Frunzio G., Guadagnuolo M., Di Gennaro L., Massaro L.   +4 more
openaire   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Assessment of Health-Oriented Layout and Perceived Density in High-Density Public Residential Areas: A Case Study of Shenzhen

Buildings
Rapid urbanization has intensified public housing development and building density, posing significant challenges to residents’ well-being and urban sustainability. With the population of the Greater Bay Area on the rise, enhancing the spatial quality of
Guangxun Cui, Menghan Wang, Yue Fan, Fei Xue, Huanhui Chen   +4 more
doaj   +1 more source

Towards the microbial home: An overview of developments in next-generation sustainable architecture. [PDF]

Microb Biotechnol, 2023
Armstrong R.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The Effect of Visual Landscape Design on the Emotional and Physiological Responses of Older Adults

Buildings
Landscape quality significantly impacts residents’ well-being through visual perception, particularly among the elderly who exhibit heightened sensitivity to environmental stimuli. Therefore, this study investigates how landscape configurations influence
Yalin Zhang, Menglin Zhang, Xiangxi Li, Keming Hou, Weijun Gao   +4 more
doaj   +1 more source