Results 31 to 40 of about 107,483 (315)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Sustainable Government Enterprise Architecture Framework

, 2021
The suitable utility of driving the enterprise architecture exercise is to utilize the enterprise architecture framework as the fundamental guidance. But there are some challenges of applying those frameworks for government and their agencies because ...
Montree Thirasakthana, Supaporn Kiattisin   +1 more
core   +1 more source

Impact of visual and textural characteristics of street walls on stress recovery

Scientific Reports
Rapid urbanization increases psychological stress among pedestrians, potentially heightening mental health disorders. This study examines the role of street walls' visual and textural characteristics in stress recovery, using Qingdao as a case study ...
Nan Zhang, Lin Zhao, Jin Shi, Weijun Gao
doaj   +1 more source

Performance Evaluation of Machine Learning Models for Predicting Energy Consumption and Occupant Dissatisfaction in Buildings

Buildings
This study evaluates the performance of 15 machine learning models for predicting energy consumption (30–100 kWh/m2·year) and occupant dissatisfaction (Percentage of Dissatisfied, PPD: 6–90%), key metrics for optimizing building performance.
Haidar Hosamo, Silvia Mazzetto
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Study on the effects of traffic noise and spring water sound at different sound pressure levels on brain dynamic activity

Scientific Reports
The correlation between sound and psychophysiological health is complex. This study explores effects of various sound pressure levels (SPLs) on psychophysiological responses, utilizing dynamic features of neural activity.
Nan Zhang, Chao Liu, Qianhui Yuan, Renyu Geng, Xi Meng, Wanxiang Yao, Weijun Gao   +6 more
doaj   +1 more source

Integrating Knowledge Graphs and Digital Twins for Heritage Building Conservation

Buildings
This study presents a framework for integrating digital twins and knowledge graphs to enhance heritage building conservation, addressing challenges in environmental stress management, material degradation, and structural integrity while preserving ...
Haidar Hosamo, Silvia Mazzetto
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Social–psychological responses to trends of sustainable architecture [PDF]

, 2023
[EN] Sustainable development became the predominant official paradigm of planning, design, and construction policies. This concept with its environmental, social, economic and cultural dimensions has been applied to the field of architecture since the ...
Daugelaite, Aurelija
core   +1 more source