Results 61 to 70 of about 107,483 (315)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Media architecture and sustainable environment [PDF]

, 2015
Being the integral part of a building, street or infrastructure, media contents shape the appearance of modern cities and affect the way their inhabitants act.
Ivanović-Šekularac, Jelena, Čikić-Tovarović, Jasna, Šekularac, Nenad   +2 more
core  

Spatial (in)justice shaping the home as a space of work

Buildings & Cities
Drawing on an extensive literature review, this study examines how injustices manifest in space and the role of space in engendering injustices when associated with working at home.
Dalia Milián Bernal, Jasmin Laitinen, Hannah Shevchenko, Oxana Ivanova, Sofie Pelsmakers, Essi Nisonen   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Editorial: New Horizons for Sustainable Architecture

Tema, 2021
Vincenzo Sapienza
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mainstreaming sustainable regeneration : a call to action

, 2012
Contents: [Part 1]. Main publication – Part 2. Supporting documentsThis report is the culmination of 18 month’s investigation by the Sustainable Development Commission into how neighbourhood regeneration can be made more sustainable.Publisher ...
Sustainable Development Commission
core  

Regional Architecture: A Sustainable Archetype for Kaho'olawe [PDF]

, 2009
This project aims to demonstrate that Regionalism integrated with a focus on Sustainability and Culture creates place specific, sustainable, and culturally appropriate architecture.
Boss, Corey
core