Results 121 to 130 of about 487,239 (300)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

N‐Geranylated Amino Acid Surfactants with Low Critical Micelle Concentrations from Abundant, Naturally Derived Starting Materials

ChemistryOpen
In this work, a simple method for the preparation of N‐alkylated amino acid surfactants in 1–2 steps is reported. These products perform comparably to existing ionic surfactants, with N‐tetrahydrogeranylated serine having a critical micelle concentration
Brett L. Pollard, Yumeng Liu, Michael G. Gardiner, Luke A. Connal   +3 more
doaj   +1 more source

Green and sustainable chemistry - The case for a systems-based, interdisciplinary approach. [PDF]

iScience, 2021
Constable DJC.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Toward system innovation for more sustainable chemistry: insights into consumers’ perceptions, knowledge, and behavior related to traceability and product design strategies along leather supply chains

Frontiers in Sustainability
The leather industry is a complex system with multiple actors that faces a fundamental transition toward more sustainable chemistry. To support this process, this article analyzes challenges of the industry and consumers’ roles as a nexus of transition ...
Charis Eisen, Julian Schenten, Anna Theis, Anna Theis, Jonas Rehn-Groenendijk, Marvin Helferich, Marvin Helferich, Helena Müller, Daniel Hanss   +8 more
doaj   +1 more source

Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry. [PDF]

ACS Sustain Chem Eng, 2021
Maertens A, Golden E, Hartung T.
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Development of Sustainable Chemistry in Madagascar: Example of the Valuation of CNSL and the Use of Chromones as an Attractant for Mosquitoes. [PDF]

Molecules, 2021
Ranarijaona MM, Rambala Rakotomena NAH, Andrianjafy MT, Ramiharimanana FD, Herinirina LC, Ramarosandratana NH, Briou B, Fajardie P, Mavingui P, Métay E, Ramanandraibe VV, Lemaire M.   +11 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Editorial: Sustainable catalytic production of bio-based heteroatom-containing compounds — volume II

Frontiers in Chemistry, 2022
Jinshu Huang, Hu Li, Yaqiong Su, Song Yang   +3 more
doaj   +1 more source