Results 111 to 120 of about 487,239 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Green Chemistry; Sustainability an Innovative Approach (Green Chemistry and Sustainability)

, 2022
Green chemistry is an approach to the design, manufacture and use of chemical products to intentionally reduce or eliminate chemical hazards. It focuses on the reduction, recycling/ elimination of the use of toxic and hazardous chemicals in production processes by finding creative, alternative routes for making the desired products that minimize the ...
openaire   +1 more source

Molecular biology: Self-sustaining chemistry [PDF]

Chemistry Central Journal, 2007
Molecular biology is an established interdisciplinary field within biology that deals fundamentally with the function of any nucleic acid in the cellular context. The molecular biology section in Chemistry Central Journal focusses on the genetically determined chemistry and biochemistry occuring in the cell.
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Green and Sustainable Chemistry in the Work of the United Nations Environment Programme: Results and Options for Future Regulation

Chemical Engineering Transactions
The expression of green and sustainable chemistry has gained significant attention around the world in recent years. Nowadays, it is evident that green and sustainable chemistry is necessary for Sustainable Development Goals (SDGs); however, the concept ...
Dalma Takó
doaj  

Synthesis of Diaryl‐ and Dialkynylphosphinates From Ubiquitous PV Sources via a Redox‐Neutral Approach

Advanced Science
Organophosphinic acids, R2P(O)(OH), and their derivatives are versatile compounds with applications in catalysis, material chemistry, biomolecular bridging, metal extraction, and flame retardancy.
Tobias Schneider, Kai Schwedtmann, Jannis Fidelius, Rosa M. Gomila, Antonio Frontera, Jan J. Weigand   +5 more
doaj   +1 more source

Toward sustainable solid-phase peptide synthesis strategy – in situ Fmoc removal

Green Chemistry Letters and Reviews
Solid-phase peptide synthesis (SPPS) is the method of choice for the synthesis of peptides for research and production purposes. Despite having several positive features, it remains a challenge to reduce the amount of solvent waste generated during the ...
Ndumiso Mthethwa, K. P. Nandhini, Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

AI4Green: An Open-Source ELN for Green and Sustainable Chemistry. [PDF]

J Chem Inf Model, 2023
Boobier S, Davies JC, Derbenev IN, Handley CM, Hirst JD.   +4 more
europepmc   +1 more source

Fifth International Conference on Renewable Resources and Biorefineries, 10-12 June 2009, Ghent, Belgium [PDF]

, 2009
B
Cukalovic, Ana
core   +1 more source