Results 41 to 50 of about 3,978,291 (244)

The Application of Intellectual Capital Approach to Promote a Sustainable Competitive Advantage in the Public Libraries of Khuzestan Province [PDF]

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2014
Purpose: This study examines the role of intellectual capital (including human capital, structural capital and relational capital) in creating a sustainable competitive advantage in the public libraries of Khuzestan.
farideh osareh, shiva yazdanfar, afshin ghasemi   +2 more
doaj  

“GREEN” HRM IN PURSUIT OF SUSTAINABLE COMPETITIVE ADVANTAGE

AICEI Proceedings, 2020
The recent years have witnessed the emergence of “Green” Human Resource Management (HRM) as one of the main strategic concepts which aims to shape employee behaviour to help organizations achieve a sustainable competitive advantage.
Snezhana Hristova, Dusica Stevceska- Srbinovska   +1 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A Importância da Visão Baseada em Recursos na Explicação da Vantagem Competitiva

Revista de Economia Mackenzie, 2006
The article reveals the theoretical implications of de Resource-Based View for understanding the firm competitive advantage. The dominant version to analysis of competitive advantage is represented by authors connected to Organizational Economics ...
Jucélio Kretzer, Emílio Araújo Menezes   +1 more
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The effect of innovation on sustainable competitive advantage through local wisdom in Padang restaurants in Pekanbaru

JPPI (Jurnal Penelitian Pendidikan Indonesia), 2023
Business competition due to a dynamic business environment that makes Padang restaurant businesses must have the ability to have a sustainable competitive advantage. This study aims to analyze the effect of innovation on sustainable competitive advantage
Annisa Mardatiilah, Rosmayani Rosmayani
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source