Results 61 to 70 of about 281,672 (303)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CHANGES IN FOOD CONSUMPTION IN POLAND – MOVING TOWARD SUSTAINABILITY? [PDF]

Annals of the Polish Association of Agricultural and Agribusiness Economists
One of the key challenges of sustainable development is the pursuit of sustainable patterns of production and consumption. Expenditure on food and non‑alcoholic beverages constitutes the most significant component of total household spending.
Monika Utzig
doaj   +1 more source

Sustainable consumption

, 2021
The aim of the chapter is to present the essence of sustainable consumption and its basic rules: Reduce-Reuse-Recycle. Minimalism and sharing economy were presented as the manifestation of the Reduce rule. Reuse requires distribution systems which will give access to preowned products (in a broader scope), thus, they will provide products with a second
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

I will if you will : towards sustainable consumption

, 2012
Report is summarised in 'I will if you will : towards sustainable consumption : a summary'.The Sustainable Consumption Roundtable (Great Britain), a joint initiative between the National Consumer Council and the Sustainable Development Commission ...
Sustainable Consumption Roundtable (Great Britain)
core  

CONSUMERS TOWARDS SUSTAINABLE FOOD CONSUMPTION

, 2020
The progressive and unprecedented growth of the Earth’s population and the shrinking of the planet’s natural resources make it necessary to look at contemporary consumption from the point of sustainable development goals. The purpose of the paper is to
Grzegorz Maciejewski, PhD, Assoc. Prof.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

I will if you will : towards sustainable consumption : a summary

, 2012
Report is summary of 'I will if you will : towards sustainable consumption : a summary'.Summary of the final report of the Sustainable Consumption Roundtable (Great Britain) sets out how a significant shift towards more sustainable lifestyles is possible
Sustainable Consumption Roundtable (Great Britain)
core  

Introduction to A Research Agenda for Sustainable Consumption Governance [Elektronisk resurs]

, 2019
Chapter 1, ‘Introduction to A Research Agenda for Sustainable Consumption Governance’ by Oksana Mont sets the scene for the book by discussing sustainable consumption as a grand challenge.
Mont, Oksana,, Lund University.
core   +1 more source