Results 71 to 80 of about 281,672 (303)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Sustainable consumption : the role of food retail

open access: yes, 2012
This submission is informed by discussion at a seminar held by the Sustainable Consumption Roundtable on 28 June on the subject of Sustainable Consumption in the 'Food industry sustainability strategy'.
Sustainable Consumption Roundtable (Great Britain)
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Double dividend : promoting good nutrition and sustainable consumption through healthy school meals

open access: yes, 2012
This report, produced by the Sustainable Consumption Roundtable tackles the issues surrounding promoting good nutrition and sustainable consumption through healthy school meals.Publisher ...
Soil Association   +6 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Sustainable Consumption Roundtable : response to ‘Taking it on’ consultation

open access: yes, 2012
This contribution to the Government’s ‘Taking It On’ consultation is from the Sustainable Consumption Roundtable (SCR), a joint initiative between the Sustainable Development Commission and the National Consumer Council.Publisher ...
Sustainable Consumption Roundtable (Great Britain)
core  

Sustainable Consumption and Production: Introduction to Circular Economy and Beyond

open access: yes, 2020
With the current path of global population growth and expansion of consumption and production, the resource availability and resilience of the Earth Systems are under threat.
Bali, Ranjula Swain,   +3 more
core   +1 more source

Sustainable consumption and production versus green capitalism: What really counts? [PDF]

open access: yes, 2023
The increasing environmental crisis, coupled with the implementation of the Sustainable Development Goals (SDGs), prompts changes in the behavior of consumers, investors, and producers.
Sinha, Geeta
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Policies for sustainable consumption

open access: yes, 2012
This document aims to provide a guide to the complexity of the sustainable consumption debate, an overview of the extensive literatures on consumer behaviour and lifestyle change, and an analysis of the policy opportunities suggested by these literatures.
Jackson, Tim, 1957-, Michaelis, Laurie
core  

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