Results 111 to 120 of about 1,998,315 (284)
Design for Sustainability: Current Trends in Sustainable Product Design and Development
Sustainability, 2009 The Design for Sustainability (D4S) concept outlines methodologies for making sustainable improvements (social, economic and environmental) to products by applying elements of life cycle thinking. D4S builds on the work of ecodesign to include economic and social concerns, and its methodology includes both incremental and radical innovation. The United
Clark, G. (author) +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
She Ji: The Journal of Design, Economics and InnovationPublic sector organizations increasingly use artificial intelligence to augment, support, and automate decision-making. However, such public AI can potentially infringe on citizens’ right to autonomy.
Kars Alfrink +5 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
An investigation into standards in sustainable design and manufacture [PDF]
, 2009 This paper reports upon the application of standards to reduce the negative environmental impacts of manufacturing through product lifecycle planning and closed loop production. By eliminating waste and retaining the energy embodied within materials and
Griffiths, BJ +3 more
core
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Dynamic life cycle impact assessment (DLCIA) in a sustainable building planning process
Scientific ReportsBuilding sector significantly contributes to the anthropogenic environmental impacts. To promote sustainable construction, life cycle assessment (LCA) serves as a useful tool to quantify the environmental impacts of a building and suggest improvement ...
Chujun Zong +2 more
doaj +1 more source
Sustainable Business Model Design
Journal of Business ModelsThis article introduces the “Sustainable Business Model Design” (SBMD) framework, an integrative methodology that synthesises sustainable business model theory with Alexandrian pattern theory. Emphasising a pragmatic interpretation of design as transformative action, the framework’s foundations are explored, seeking to consolidate the theoretical ...
Lüdeke-Freund, Florian +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source