Results 91 to 100 of about 363,649 (264)

Dynamic life cycle impact assessment (DLCIA) in a sustainable building planning process

Scientific Reports
Building sector significantly contributes to the anthropogenic environmental impacts. To promote sustainable construction, life cycle assessment (LCA) serves as a useful tool to quantify the environmental impacts of a building and suggest improvement ...
Chujun Zong, Farzan Banihashemi, Werner Lang   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Envisioning Contestability Loops: Evaluating the Agonistic Arena as a Generative Metaphor for Public AI

She Ji: The Journal of Design, Economics and Innovation
Public sector organizations increasingly use artificial intelligence to augment, support, and automate decision-making. However, such public AI can potentially infringe on citizens’ right to autonomy.
Kars Alfrink, Ianus Keller, Mireia Yurrita Semperena, Denis Bulygin, Gerd Kortuem, Neelke Doorn   +5 more
doaj   +1 more source

Exploring journeys from sustainable design to design for sustainability

During the past two decades, educating students about sustainability issues has been a concern when designing engineering schools curricula. One could think that nowadays students are trained to take into account the multiple dimensions of sustainability when addressing a project-based design challenge. Is this really the case?
Laperrouza, Marc, Mélo, Michka
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effects of climate change on open air heritage: a review and the situation in the region of Mediterranean

Heritage Science
This paper collects research information and registered data regarding the relationship between climate change and heritage, aiming to present a comprehensive state of studies and research on the subject.
Marina Panagiota P. Nastou, Stelios C. Zerefos   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source