Results 111 to 120 of about 363,649 (264)
Sustainable Design of New Ionic Forms of Vitamin B3 and Their Utilization as Plant Protection Agents. [PDF]
J Agric Food Chem, 2022 Stachowiak W +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Mechanical ventilators for low- and middle-income countries: informing a context-specific and sustainable design. [PDF]
Br J Anaesth, 2022 Gallifant J +6 more
europepmc +1 more source
Designing sustainability for all or co-designing sustainability with all? [PDF]
, 2019 The paper discusses the critical difference of modernist approach of designing for- and increasing approaches of designing with- or across-, in this case with/across the overall eco-system. The research aims to engage all possible agencies in urban environment for its shift from Anthropocene.
openaire
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
One Step before Synthesis: Structure-Property-Condition Relationship Models to Sustainable Design of Efficient TiO2-Based Multicomponent Nanomaterials. [PDF]
Int J Mol Sci, 2022 Mikolajczyk A, Falkowski D.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Sustainable Design Approach for Modeling Bioprocesses from Laboratory toward Commercialization: Optimizing Chitosan Production. [PDF]
Polymers (Basel), 2021 Meramo S +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source