Results 81 to 90 of about 11,470,632 (278)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A sustainable new deal : a stimulus package for economic, social and ecological recovery [PDF]
, 2012 Sustainable Development Commission's advice to Government on how to revive the UK's economy through a green recovery package.Publisher ...
Sustainable Development Commission
core +2 more sources
Built HeritageInterior thermal insulation has been widely used to improve energy efficiency and indoor comfort of historic buildings. However, traditional vapour-tight insulation materials strongly influence the hygrothermal behaviour of facades, which may lead to ...
Xinyuan Dang +3 more
doaj +1 more source
Climate Change and Heritage Management; the case study of the ancient Greek theatre of Lindos in Rhodes, Dodecanese [PDF]
E3S Web of ConferencesThe importance of heritage during the current times of transition to the technological progress has recently obtained much attention, especially for the risks of degradation related with the climate change.
Nastou Marina Panagiota P. +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The role of artificial intelligence in environmental sustainability [PDF]
E3S Web of ConferencesThe climate change is the most important challenge of the 21st-century, worldwide. Artificial Intelligence (AI) can play a key role in achieving environmental sustainability.
Patoucha Areti, Gareiou Zoe
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Integrated Regression and Cluster Analysis for Cost Benefit Evaluation of Energy Retrofit Interventions in Hellenic Schools [PDF]
E3S Web of ConferencesThis study introduces and explains a methodology that integrates regression and cluster analysis of Energy Performance Certificates data to evaluate the cost effectiveness of energy retrofit measures in Greek school buildings.
Petroliagki Margarita, Giannarou Sophia
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nature-Based SolutionsRising sea levels and stormwater flooding threaten coastal ecosystems like wetlands, exacerbating urban sustainability challenges. Urban Living Labs and NBS propose decentralised, community-driven approaches emphasising resilience, circularity, symbiosis,
Manuel Higgs Morgado +3 more
doaj +1 more source