Results 71 to 80 of about 11,470,632 (278)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Sustainable development : the key to tackling health inequalities [PDF]
, 2012 In November 2008, Professor Sir Michael Marmot was asked to advise the Secretary of State for Health on the future development of a health inequalities strategy in England post-2010.
Sustainable Development Commission
core +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Environmental Sciences EuropeBackground Wastewater discharges from the old pulp and paper industry led to the accumulation of contaminated wood pulping fibers and debris—referred to as fiberbanks (FB)—in the Baltic Sea and freshwater bodies across Sweden and other pulp-producing ...
Gabriela L. Paladino +5 more
doaj +1 more source
Investigation through questionnaires of the impact of tourist flows on environmental degradation: Case study in the municipality of Mykonos, Greece [PDF]
E3S Web of ConferencesThis paper deals with the environmental impacts of tourism when tourism flows exceed the carrying capacity of a touristic destination by focusing on the island of Mykonos, which, in recent years, has become the most attractive and popular tourist ...
Katsoudas Konstantinos, Kaika Dimitra
doaj +1 more source
Micromachines, 2020 Fabricating multi-cell constructs in complex geometries is essential in the field of tissue engineering, and three-dimensional (3D) bioprinting is widely used for this purpose. To enhance the biological and mechanical integrity of the printed constructs,
Tiffany Cameron +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Standard Design Process for Sustainable Design
Procedia Computer Science, 2015 AbstractThis exploratory research examined the degree of adoption and impact of the concepts of Building Information Model (BIM), Integrated Project Delivery (IPD), Integrated Design Process (IDP) and Building Energy Simulation (BES) on the design processes of advanced architectural firms when executing sustainable design. Six offices identified by the
openaire +2 more sources
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source