Results 101 to 110 of about 508,137 (303)
Synthetic chimeric nucleases function for efficient genome editing
Nature Communications, 2019 CRISPR-Cas systems have well characterized, modular structures. Here the authors use that architecture to design a Cas12a library of 560 synthetic chimeras, with altered PAM preferences and specificities.
R. M. Liu +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Future perspectives on sustainable tribology [PDF]
, 2012 This paper highlights the future perspectives of sustainable tribology by examining the economic, environmental and social impact of three tribological case studies.
Hadfield, M. +10 more
core +1 more source
, 2005 Solar energy can replace fossil and nuclear fuels over the next 50 years, thus creating a truly sustainable energy supply system. Diversity of solar energy sources is the key to a stable energy supply. Solar thermal, photovoltaics and wind energy are likely to dominate the solar energy mix.
openaire +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Delaware value of solar: a study of the costs and benefits of net metering
This report provides a cost-benefit analysis of net metering for solar energy.
Delaware Sustainable Energy Utility
core +1 more source
Energy Strategy ReviewsThis research proposes a new approach to increase the utilization of electric vehicles (EVs) by establishing solar-powered charging stations. Using ArcGIS 10 8.2 software, the optimal locations for the construction of these stations were identified and ...
Amir Naseri +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers +7 more
wiley +1 more source