Results 111 to 120 of about 511,275 (304)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
2025 Delaware Energy Fund report [PDF]
This report, created in accordance with House Substitute 1 for House Bill 50 of the 153rd General Assembly, describes the activity of the Delaware Energy Fund in 2025.
Delaware Sustainable Energy Utility
core
National infrastructure : embedding sustainable development in decision making [PDF]
, 2012 By taking a sustainable development approach, local authorities and their partners can play a leading role in delivering integrated environmental, social and economic improvements at the local level.Publisher ...
Sustainable Development Commission
core
Synthetic chimeric nucleases function for efficient genome editing
Nature Communications, 2019 CRISPR-Cas systems have well characterized, modular structures. Here the authors use that architecture to design a Cas12a library of 560 synthetic chimeras, with altered PAM preferences and specificities.
R. M. Liu +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Stock take : delivering improvements in existing housing [PDF]
, 2012 The Sustainable Development Commission was commissioned by the Office of the Deputy Prime Minister to examine the potential for significantly improved resource efficiency in the existing housing stock.
Sustainable Development Commission
core
Energy Strategy ReviewsThis research proposes a new approach to increase the utilization of electric vehicles (EVs) by establishing solar-powered charging stations. Using ArcGIS 10 8.2 software, the optimal locations for the construction of these stations were identified and ...
Amir Naseri +3 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source