Results 151 to 160 of about 29,217 (258)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Global maternal and infant health monitoring systems: a scoping review protocol. [PDF]

BMJ Open
Al-Habbal K, Hassan Z, Kaddoura R, Yousef S, Fetty J.   +4 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery.

Green Chem
Patil P, Ingenito E, Fusco R, Capriello I, Guan Z, Bhalkikar A, Gibbons J, Korba T, Bashkyrtsev S, Tkachenko O, Dömling A.   +10 more
europepmc   +1 more source

Evaluating automated or artificial intelligence search tools for evidence synthesis. [PDF]

J Med Libr Assoc
Featherstone R.
europepmc   +1 more source

Role of Libraries in Sustainable Development

Libraries are crucial achieving on sustainable development (SD) by providinguniversal access to information, Fostering literacy and digital skills. Supporting researchand innovation, Promoting environmental awareness and acting as community hubs forengagement and social inclusion.
openaire   +2 more sources

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

A High-quality Reference Genome and Tissue Expression Atlas for the European Lobster (Homarus gammarus). [PDF]

Genome Biol Evol
Paris JR, Jenkins TL, Ferrer Obiol J, Gundappa MK, Regan T, Campbell L, Maslen GL, Alvarez-Jarreta J, Dyer S, Jeffries AR, Murray G, Farbos A, Bickley LK, Verbruggen B, Bateman KS, Daniels CL, Ellis CD, Ashton TJ, Tyler CR, Stentiford GD, Houston RD, Bean TP, van Aerle R, Macqueen DJ, Stevens JR, Santos EM.   +25 more
europepmc   +1 more source

Green Libraries and Sustainability Initiative

Green libraries and sustainability initiatives aim to integrate environmentally responsible practices into library operations, infrastructure, and community engagement. By adopting eco-friendly building designs, energy-efficient systems, waste reduction strategies, and water conservation measures, libraries significantly reduce their environmental ...
openaire   +2 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source