Results 31 to 40 of about 74,860 (219)

Enhancing High-Temperature Oxidation Stability of Recycled Carbon Fibers Through Ceramic Coating

C
Carbon fiber-reinforced composites (CFRCs) have attracted considerable attention in recent years due to their excellent properties, enabling their use across various sectors.
Carmela Borriello, Sabrina Portofino, Loredana Tammaro, Pierpaolo Iovane, Gabriella Rametta, Sergio Galvagno   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Developing a Supportive Organisational Culture for Continuous Improvement in Manufacturing Firms in Saudi Arabia

Administrative Sciences
Continuous improvement (CI) is vital for Saudi manufacturing firms to remain competitive in the global market. However, cultural factors significantly influence CI adoption.
Adel Algethami, Fadi Assad, John Patsavellas, Konstantinos Salonitis   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Recent developments in bio-based polyethylene: Degradation studies, waste management and recycling

Heliyon, 2023
Nowadays, the tendency to replace conventional fossil-based plastics is increasing considerably; there is a growing trend towards alternatives that involve the development of plastic materials derived from renewable sources, which are compostable and ...
Manuel Burelo, Josué David Hernández-Varela, Dora I. Medina, Cecilia D. Treviño-Quintanilla   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Microstructure and Mechanical Properties of Magnesium ZRE1 (Mg-Zn-Zr) Alloy with Rare Earth Element (Samarium) Addition

International Journal of Technology
The influences of rare earth (RE) samarium (Sm) added contents to ZRE1 (Mg-Zn-Zr) magnesium (Mg) cast alloy over strength properties to be investigated.
Ikhwan Shah Tisadi Tukiat, Nur Kamilah Yusuf, Haikal Khaireez, Sami Al-Alimi, Mohd Amri Lajis, Shazarel Shamsudin, Nasha Emieza Ruhaizat   +6 more
doaj   +1 more source

Development of Hot Equal Channel Angular Processing (ECAP) Consolidation Technique in the Production of Boron Carbide(B4C)-Reinforced Aluminium Chip (AA6061)-Based Composite

International Journal of Renewable Energy Development, 2021
The production of metal matrix composites (MMCs) through recycled materials is a cost-saving process. However, the improvement of the mechanical and physical properties is another challenge to be concerned. In this study, recycled aluminium 6061 (AA6061)
Sami Al-Alimi, Mohd Amri Lajis, Shazarel Shamsudin, Nur Kamilah Yusuf, Boon Loong Chan, Djamal Hissein Didane, Mohammed H. Rady, Huda M. Sabbar, Munthader S. Msebawi   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source