Results 41 to 50 of about 623,411 (305)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Special Issue: Smart Resilient Manufacturing

Applied Sciences, 2022
During the past decades, the global manufacturing industries have been reshaped by the rapid development of advanced technologies, such as cyber-physical systems, Internet of Things, artificial intelligence (AI), machine learning, cloud/edge computing ...
Jinzhi Lu, Xiaochen Zheng, Dimitris Kiritsis   +2 more
doaj   +1 more source

Sustainable CO2 adsorbents prepared by coating chitosan onto mesoporous silicas for large-scale carbon capture technology [PDF]

, 2015
In this article, we report a new sustainable synthesis procedure for manufacturing chitosan/silica CO2 adsorbents. Chitosan is a naturally abundant material and contains amine functionality, which is essential for selective CO2 adsorptions.
Ganin, Alexey Y., Sneddon, Gregor, Yiu, Humphrey H. P.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Enhancing High-Temperature Oxidation Stability of Recycled Carbon Fibers Through Ceramic Coating

C
Carbon fiber-reinforced composites (CFRCs) have attracted considerable attention in recent years due to their excellent properties, enabling their use across various sectors.
Carmela Borriello, Sabrina Portofino, Loredana Tammaro, Pierpaolo Iovane, Gabriella Rametta, Sergio Galvagno   +5 more
doaj   +1 more source

Botanical Fabrication: A research project at the intersection of design, botany and horticulture [PDF]

, 2015
‘Botanical Fabrication’ is an on-going research initiative which investigates how an understanding of botany and horticultural techniques can challenge the design process and lead to alternative sustainable manufacturing or ‘eco-facturing’ tools.
Collet, Carole, Foissac, Guillaume
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Advancing sustainable manufacturing: a case study on plastic recycling

Production and Manufacturing Research: An Open Access Journal
This paper reviews sustainable manufacturing practices by integrating environmental, economic, and social dimensions of sustainability, emphasizing that environmental aspects are most frequently addressed (53.8%), followed by economic (34.6%) and social (
Javier Maldonado-Romo, Rafiq Ahmad, Pedro Ponce, Juana Isabel Mendez, Omar Mata, Mario Rojas, Luis Montesinos, Arturo Molina   +7 more
doaj   +1 more source

The potential of additive manufacturing in the smart factory industrial 4.0: A review [PDF]

, 2019
Additive manufacturing (AM) or three-dimensional (3D) printing has introduced a novel production method in design, manufacturing, and distribution to end-users.
Dehghanghadikolaei, Amir, Emamian, Sattar S., Fotovvati, Behzad, Gisario, Annamaria, Mehrpouya, Mehrsha, Vosooghnia, Alireza   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source