Results 61 to 70 of about 623,411 (305)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Uncertain programming model for designing multi-objective reverse logistics networks

Cleaner Logistics and Supply Chain
Given the contradiction between the rapid growth of products and the modest recovery rate of end-of-life products, there is a pressing need to understand the societal significance of establishing a reverse logistics network for end-of-life products. This
Hanbing Xia, Zhiyuan Chen, Jelena Milisavljevic-Syed, Konstantinos Salonitis   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Additive manufacturing – a sustainable manufacturing route [PDF]

MATEC Web of Conferences, 2017
Additive Manufacturing (AM) technologies allow developing and manufacturing very complex shaped parts and functional products with a high level of customization, being a great alternative to Traditional Manufacturing (TM) methods like injection molding, die-casting or machining.
Frăţilă, Domniţa, Rotaru, Horaţiu
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Microstructure and Mechanical Properties of Magnesium ZRE1 (Mg-Zn-Zr) Alloy with Rare Earth Element (Samarium) Addition

International Journal of Technology
The influences of rare earth (RE) samarium (Sm) added contents to ZRE1 (Mg-Zn-Zr) magnesium (Mg) cast alloy over strength properties to be investigated.
Ikhwan Shah Tisadi Tukiat, Nur Kamilah Yusuf, Haikal Khaireez, Sami Al-Alimi, Mohd Amri Lajis, Shazarel Shamsudin, Nasha Emieza Ruhaizat   +6 more
doaj   +1 more source

Driving factor of sustainable environmental manufacturing practices in Malaysia [PDF]

, 2014
An increased demand has been placed on the manufacturing industries to be more responsible to their environment with respect to their operational activities.This demand is due to various antecedent factors driving sustainable environmental practices in ...
Adebambo, Hameed O., Ashari, Hasbullah, Nordin, Norani   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

An Augmented Reality Based Human-Robot Interaction Interface Using Kalman Filter Sensor Fusion

Sensors, 2019
In this paper, the application of Augmented Reality (AR) for the control and adjustment of robots has been developed, with the aim of making interaction and adjustment of robots easier and more accurate from a remote location.
Chunxu Li, Ashraf Fahmy, Johann Sienz
doaj   +1 more source

Future of business models in manufacturing [PDF]

, 2017
In order to achieve systematic change in pursuit of sustainable manufacturing, both a strategic long-term perspective employing methods from future studies and a concrete implementation of the knowledge gained in sustainable business models are necessary.
Barquet, Ana-Paula, Kohl, Holger, Seidel, Johannes, Seliger, Günther   +3 more
core   +1 more source