Results 71 to 80 of about 623,411 (305)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Circular economy strategy based on digital technologies and the S4 framework: a case study on smartphones

International Journal of Sustainable Engineering
Smartphones are indispensable tools for daily tasks; nevertheless, their short lifespan of about two years contributes to a disproportionate increase in environmental waste.
Javier Maldonado-Romo, Juana Isabel Méndez, Mario Rojas, Luis Montesinos, Pedro Ponce, Arturo Molina   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Lack of verified Inclusive Technology for Workers with disabilities in industry 4.0: a systematic review

International Journal of Sustainable Engineering
Technologies from Industry 4.0 enhance human skills and capabilities in production. These advanced manufacturing and digital technologies unlock opportunities to integrate individuals with unique abilities into industrial environments, helping to attain ...
Mario Rojas, David C. Balderas, Javier Maldonado, Pedro Ponce, Diego Lopez-Bernal, Arturo Molina   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Code for sustainable homes: opportunities or threats for offsite manufacturing and mass-customization? [PDF]

, 2013
This study intends to, firstly, discuss current status of zero carbon homes in the UK, and secondly, to investigate the feasibility of using offsite construction methods to deliver mass customised zero carbon homes.
Hadjri, Karim, Hashemi, Arman
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Natural Language Processing (NLP)-Based Frameworks for Cyber Threat Intelligence and Early Prediction of Cyberattacks in Industry 4.0: A Systematic Literature Review

Applied Sciences
This study provides a systematic overview of Natural Language Processing (NLP)-based frameworks for Cyber Threat Intelligence (CTI) and the early prediction of cyberattacks in Industry 4.0. As digital transformation accelerates through the integration of
Majed Albarrak, Konstantinos Salonitis, Sandeep Jagtap   +2 more
doaj   +1 more source

From failure to success: a framework for successful deployment of Industry 4.0 principles in the aerospace industry [PDF]

International Journal of Industrial Engineering and Operations Management
Purpose – The paper proposes a framework for the successful deployment of Industry 4.0 (I4.0) principles in the aerospace industry, based on identified success factors.
Sumit Gupta, Deepika Joshi, Sandeep Jagtap, Hana Trollman, Yousef Haddad, Yagmur Atescan Yuksek, Konstantinos Salonitis, Rakesh Raut, Balkrishna Narkhede   +8 more
doaj   +1 more source

Smart Change in Strategy: IBM‘s Response to Challenging Times [PDF]

, 2012
International Business Machines, or IBM, has been an indisputable force in the communications industry, leading the world into the modern, global technological age.
Gingerich, Elizabeth
core   +1 more source