Results 91 to 100 of about 5,278,876 (305)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Developing a virtual reality and AI-based framework for advanced digital manufacturing and nearshoring opportunities in Mexico

Scientific Reports
The growing expansion of the manufacturing sector, particularly in Mexico, has revealed a spectrum of nearshoring opportunities yet is paralleled by a discernible void in educational tools for various stakeholders, such as engineers, students, and ...
Pedro Ponce, Brian Anthony, Russel Bradley, Javier Maldonado-Romo, Juana Isabel Méndez, Luis Montesinos, Arturo Molina   +6 more
doaj   +1 more source

Sustainable manufacturing. Bibliometrics and content analysis

, 2020
Businesses have practiced and examined lean and green manufacturing principles for the last 25 years, but the sustainability challenges that we face today are still significantly potent.
Y. Bhatt, Karminder Ghuman, A. Dhir
semanticscholar   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Computer Vision Approach for Performance Tracking of Robotic Compliant Systems

Engineering Reports
Characterization and testing of 3D‐printed robotic compliant systems for lifespan assessment is time‐consuming and costly. For this reason, this work introduces a computer vision approach for automated, non‐invasive monitoring of grippers and evaluation ...
E. Morales‐Vargas, R. Q. Fuentes‐Aguilar, G. Hernández‐Melgarejo, Enrique Cuan‐Urquizo   +3 more
doaj   +1 more source

A novel mathematical model for predicting a sustainable selective laser melting and controlled densification

International Journal of Sustainable Engineering
We introduce the innovative concept of Sustainable Laser Energy Consumption (SLEC, ε) that promotes sustainable metal additive manufacturing practices while maintaining productivity and tailored densification in the Selective Laser Melting (SLM) process.
Jorge A. Estrada-Díaz, Alex Elías-Zúñiga, Oscar Martínez-Romero, Luis M. Palacios-Pineda, Rigoberto Guzmán-Nogales, Luis D. Cedeño-Viveros, Daniel Olvera-Trejo   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Smart interfaces to assist the operator in the context of industry 4.0 with a 5S human-centric approach

Wearable Technologies
This paper explores the integration of haptic gloves and virtual reality (VR) environments to enhance industrial training and operational efficiency within the framework of Industry 4.0 and Industry 5.0.
Mario Rojas, Javier Maldonado-Romo, Juana Isabel Mendez, Pedro Ponce, Arturo Molina   +4 more
doaj   +1 more source