Results 101 to 110 of about 4,465,949 (334)

Promoting Sustainable Mobility: To What Extent Is “Health” Considered by Mobility App Studies? A Review and a Conceptual Framework

Sustainability, 2021
Promoting cycling and walking in cities improves individual health and wellbeing and, together with public transport, promotes societal sustainability patterns. Recently, smartphone apps informing and motivating sustainable mobility usage have increased.
Heike Marquart, Julia Schuppan
semanticscholar   +1 more source

Pathways for accelerating transitions towards sustainable mobility in European cities [PDF]

, 2021
Meeting the European Green Deal’s (EGD) target of climate-neutrality by 2050 will require a 90% reduction in emissions from the transport sector, as formulated in the European Commission’s Communication on the EGD in December 2019 (EC, 2019a ...
Smeds, E., Cavoli, C.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Custom-Designed Pre-Chamber: Investigating the Effects on Small SI Engine in Active and Passive Modes

Energies, 2023
This work shows the results of an experimental campaign carried out in two spark ignition engines, a small optical research engine and its commercial counterpart, using a turbulent ignition system (pre-chamber) specifically designed for small engines ...
Paolo Sementa, Cinzia Tornatore, Francesco Catapano, Silvana Di Iorio, Bianca Maria Vaglieco   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Persuasive Design for Sustainable Mobility

India HCI 2021, 2021
With the rising pollution levels due to the transport sector, managing the mobility of people has become one of the toughest environmental and social challenges. This makes sustainability the defining factor for the future of mobility. This paper aims to identify the problems faced by the people in using sustainable modes for daily travel.
Tanya Gupta, Neelakshi Kar, Wricha P. Mishra, Gareth Loudon   +3 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of Pyrolysis Temperature on Biochar Produced from Lignin–Rich Biorefinery Residue

ChemEngineering, 2022
The biorefinery concept is growing rapidly for bio-based production of fuels and products, and steam explosion is by far the most applied pre-treatment technology allowing the delignification of lignocellulosic biomass.
Corinna Maria Grottola, Paola Giudicianni, Fernando Stanzione, Raffaele Ragucci   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source