Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
SDC Submission to NI Assembly Environment Committee : inquiry into climate change [PDF]
, 2012 This document is the Sustainable Development Commission Northern Ireland’s submission to the Northern Ireland Assembly Environment Committee inquiry into climate change.Publisher ...
Sustainable Development Commission Northern Ireland
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Soybean genetic resources contributing to sustainable protein production. [PDF]
Theor Appl Genet, 2022 Guo B +14 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Ymgynghoriad ar fframwaith amgylchedd naturiol Cymru : ymateb i adborth Comisiwn Datblygu Cynaliadwy [PDF]
, 2012 Welsh language version of 'Wales natural environment framework consultation : Sustainable Development Commission feedback response'.Evidence provided in response to the Welsh Assembly consultation entitled 'A living Wales : a new framework for our ...
Sustainable Development Commission Wales
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Correction to: Soybean genetic resources contributing to sustainable protein production. [PDF]
Theor Appl Genet, 2022 Guo B +14 more
europepmc +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Sustainable lives : what will sustainable lifestyles look like? : a provocation [PDF]
, 2012 In Sustainable Lives, published in 2009, Alan Knight, ex-SDC Commissioner for Business and Sustainable Consumption, outlines ten key principles for determining what a sustainable lifestyle might look like.
Knight, Alan +1 more
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The potential of young vegetative quinoa (Chenopodium quinoa) as a new sustainable protein-rich winter leafy crop under Mediterranean climate. [PDF]
PLoS One, 2023 Rubinovich L +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source