Results 31 to 40 of about 14,654,306 (255)

Numerical investigation of sustainable groundwater yields for the Wiang Pa Pao aquifer system in northern Thailand [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2018
Because of ongoing economic growth, the Kok River Basin in northern Thailand may suffer from near future water stress and its long-term sustainable groundwater yield has to be put into question.
Phatcharasak Arlai, Manfred Koch, Arun Lukjan   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Opportunities for private sector participation in agricultural water development and management [PDF]

, 2014
Irrigation management / Private sector / Public sector / Public policy / Private investment / Participatory management / Privatization / Financing / Farmers / Households / Water harvesting / Africa South of ...
Penning de Vries, Frits, Inocencio, Arlene, Inocencio, Arlene B., Sally, Hilmy, Penning de Vries, Frits W.T.   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrated Assessment of Metal Contamination of Soils, Sediments, and Runoff Water in a Dry Riverbed from a Mining Area Under Torrential Rain Events

Land
Dry riverbeds can transport mining waste during torrential rain events, disseminating pollutants from mining areas to natural ecosystems. This study evaluates the impact of these mine wastes on soils, sediments, and runoff/pore water in the La ...
José Cuevas, Ángel Faz, Silvia Martínez-Martínez, Juan Beltrá, José A. Acosta   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Understanding the Application of Plant Extracts in Wound Healing of Fish: A Comprehensive Review

Aquaculture, Fish and Fisheries
This review explores the latest developments in the use of plant extracts to promote fish wound healing. Healing from wounds is an essential part of maintaining fish health, especially in aquaculture where injuries can result in large losses.
Christian Larbi Ayisi, Samuel Ayeh Osei, Gertrude Dzifa Mensah, Cecilia Asemah   +3 more
doaj   +1 more source

Multifunctional Greenway Approach for Landscape Planning and Reclamation of a Post-Mining District: Cartagena-La Unión, SE Spain

Land
Establishing a sustainable framework for remediating environmental degradation caused by historical mining operations in the Sierra Minera of Cartagena-La Unión, southeastern Spain, is a critical imperative.
Angel Faz, Sebla Kabas, Raul Zornoza, Silvia Martínez-Martínez, Jose A. Acosta   +4 more
doaj   +1 more source

Water Security and Cross-Border Water Management in the Kabul River Basin

, 2023
This paper investigates the collaborative and benefit-sharing approaches to conflict management in the management of cross-border water resources for the sustainable development of the Kabul River Basin riparian states of Afghanistan and Pakistan.
Ravichandran Moorthy, Sumayya Bibi
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source