Results 211 to 220 of about 386,974 (265)

Sterility of Sustained-release Buprenorphine

Journal of the American Association for Laboratory Animal Science, 2022
Sustained-release formulations of controlled substances are commonly used to provide analgesia in research animals. These formulations represent refinements that offer the advantage of prolonged, multiday pain relief with a single injection, thereby decreasing handling stress in animals and saving time for scientists.
Shraddha I, Cantara, Crystal, Gergye, Vanessa K, Lee, Michael, Huerkamp   +3 more
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Sustained release hormonal preparations

Journal of Steroid Biochemistry, 1970
ABSTRACT Determination of radioactivity in urine, faeces and various organs in rats was used to monitor the absorption of labelled 6-methyl-17α-acetoxy-4,6-pregnadiene-3,20-dione from polydimethylsiloxane implants or after oral administration. Given orally, peak plasma levels were obtained 4 h after administration. It took about 4 days to reach
Fred A. Kincl, K. Sundaram, C. C. Chang, Harry W. Rudel   +3 more
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Sustained-Release Butorphanol Microparticles

Drug Development and Industrial Pharmacy, 2000
Various butorphanol-loaded microparticles have been prepared with a biodegradable copolymer P(FAD-SA) of erucic acid dimer (FAD) and sebacic acid (SA) and a copolymer P(CPP-SA) of carboxyphenoxypropane (CPP) and SA using a melt compounding and milling method. Drug release was measured in vitro following incubation of drug-loaded microparticles in water
H C, Chang, L C, Li
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Indomethacin Sustained-Release?

Drug Intelligence & Clinical Pharmacy, 1984
Recently, many new formulations of older drugs have been marketed as sustained-release preparations. Only some of these compounds have scientific rationale supporting their development. At least two inherent properties of a drug are desirable in considering its reformulation into a sustained-release entity.
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Sustained Release Intravitreal Dexamethasone

Journal of Ocular Pharmacology and Therapeutics, 1996
Sustained intravitreal levels of dexamethasone may be useful in the treatment of proliferative vitreoretinopathy (PVR). The preparation and evaluation of an implantable system for intravitreal sustained release of dexamethasone is described. Pellets of dexamethasone were coated in biocompatible, nonerodible polymers and the release rate tested in vitro.
D P, Hainsworth, P A, Pearson, J D, Conklin, P, Ashton   +3 more
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Sustained-release aspirin in children

The Journal of Pediatrics, 1968
Serial plasma salicylate levels were measured in children with acute rheumatic fever following a single dose and maintenance therapy with different regimens of regular and sustained-release aspirin preparations. The plasma salicylate levels were comparable following a single equivalent dose of regular and sustained-release aspirin preparations except ...
S P, Gotoff, S A, McCue, P W, Wendell
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Tramadol Sustained-Release Capsules

Drugs, 2006
Tramadol is a synthetic, centrally acting analgesic. A sustained-release (SR) capsule formulation of tramadol gradually releases active drug, allowing for twice-daily dosing. Compared with tramadol SR tablets, tramadol SR capsules produced a smoother plasma concentration profile, with more gradual absorption and lower peak concentrations.
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Pharmacokinetics of sustained-release etodolac

Rheumatology International, 1993
Etodolac exhibits linear pharmacokinetics, good oral bioavailability, greater than 99% protein binding, a low oral clearance (almost exclusively non-renal), a relatively small volume of distribution and a half-life that averages 7.3 +/- 4.0 h. No significant pharmacokinetic differences have been noted in patients with mild to moderate renal impairment,
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Sustained-Release Procainamide and Neutropenia

Annals of Internal Medicine, 1984
Excerpt To the editor: Ellrodt and colleagues (1) recently reported an association between severe neutropenia and the use of sustained-release procainamide.
S, Anderson, N K, Wenger
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