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Indomethacin Sustained-Release?

Drug Intelligence & Clinical Pharmacy, 1984
Recently, many new formulations of older drugs have been marketed as sustained-release preparations. Only some of these compounds have scientific rationale supporting their development. At least two inherent properties of a drug are desirable in considering its reformulation into a sustained-release entity.
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Sustained-Release Butorphanol Microparticles

Drug Development and Industrial Pharmacy, 2000
Various butorphanol-loaded microparticles have been prepared with a biodegradable copolymer P(FAD-SA) of erucic acid dimer (FAD) and sebacic acid (SA) and a copolymer P(CPP-SA) of carboxyphenoxypropane (CPP) and SA using a melt compounding and milling method. Drug release was measured in vitro following incubation of drug-loaded microparticles in water
H C, Chang, L C, Li
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Sustained release hormonal preparations

Journal of Steroid Biochemistry, 1970
ABSTRACT Determination of radioactivity in urine, faeces and various organs in rats was used to monitor the absorption of labelled 6-methyl-17α-acetoxy-4,6-pregnadiene-3,20-dione from polydimethylsiloxane implants or after oral administration. Given orally, peak plasma levels were obtained 4 h after administration. It took about 4 days to reach
Fred A. Kincl   +3 more
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Pharmacokinetics of sustained-release etodolac

Rheumatology International, 1993
Etodolac exhibits linear pharmacokinetics, good oral bioavailability, greater than 99% protein binding, a low oral clearance (almost exclusively non-renal), a relatively small volume of distribution and a half-life that averages 7.3 +/- 4.0 h. No significant pharmacokinetic differences have been noted in patients with mild to moderate renal impairment,
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Tramadol Sustained-Release Capsules

Drugs, 2006
Tramadol is a synthetic, centrally acting analgesic. A sustained-release (SR) capsule formulation of tramadol gradually releases active drug, allowing for twice-daily dosing. Compared with tramadol SR tablets, tramadol SR capsules produced a smoother plasma concentration profile, with more gradual absorption and lower peak concentrations.
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Oral Sustained-Release Medications

AJN, American Journal of Nursing, 1963
F OR MANY YEARS, there has been an active interest in modifying oral preparations of drugs to delay and prolong their absorption from the gastrointestinal tract so that a sustained action might be obtained. About 10 years have passed since the first long-acting dosage form for oral use was introduced(1).
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