Results 221 to 230 of about 374,998 (364)

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Additional file 1 of Clinical outcomes of arthroscopic all-inside anterior talofibular ligament suture augmentation repair versus modified suture augmentation repair for chronic ankle instability patients

Dahai Hu, Nan Wang, Huajun Wang, Dongyi Fan, Qiang Teng, Xiaofei Zheng, Huige Hou   +6 more
openalex   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Use of barbed suture for continuous urethro-vesical anastomosis in open retropubic radical prostatectomy: A new and practical approach. [PDF]

Int J Surg Case Rep
Erbin A, Mod M, Can O, Sagir AE, Canat HL.   +4 more
europepmc   +1 more source

175. Cost Comparison Between Spring-assisted Cranioplasty and Open Cranial Vault Remodeling as the Primary Surgical Management of Single-suture Craniosynostosis

Samantha D. Morin, Colton Fernstrum, Rebecca Carlson, Gidarell Bryant, Kendall C. Pitre, H. H. Taylor, Laura S. Humphries, Ian C. Hoppe   +7 more
openalex   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Comparative Analysis of Aesthetic Abdominoplasty Versus Simple Abdominal Closure in Deep Inferior Epigastric Perforator Flap Breast Reconstruction. [PDF]

Plast Reconstr Surg Glob Open
Cherubino M, Paganini F, Lombardo GAG, Bravo Gomez M, Gurunian R.   +4 more
europepmc   +1 more source

Local Anesthetic Effect of Amitriptyline versus Lidocaine in Isolated Lesion of the Limb Requiring Primary Suturing; Assessing a Novel Therapeutic Agent

, 2019
Rasoul Salimi, Rasool Haddadi, Abbas Moradi, Farnoush Jalilvand, Farzin Firozian   +4 more
openalex   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Madison Objective Self-Assessment Tool: A Reliable and User-Friendly Approach for Objective Self-Assessment in Microvascular Anastomosis Training. [PDF]

Neurosurg Pract
Keles A, Dumot C, Hatipoglu Majernik G, Chebel R, Gurbuz MS, Gasimov TA, Oriola GG, Elbayomy AM, Acitores Cancela A, Erginoglu U, Ozaydin B, Martinez Santos JL, Baskaya MK.   +12 more
europepmc   +1 more source