Results 41 to 50 of about 312,815 (313)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

High-sensitivity detection of Mycobacterium tuberculosis DNA in tongue swab samples

Journal of Clinical Microbiology
Tongue swab (TS) sampling combined with quantitative PCR (qPCR) to detect Mycobacterium tuberculosis (MTB) DNA is a promising alternative to sputum testing for tuberculosis (TB) diagnosis.
Alaina M. Olson, Rachel C. Wood, Kris M. Weigel, Alexander J. Yan, Katherine A. Lochner, Rane B. Dragovich, Angelique K. Luabeya, Paul Yager, Mark Hatherill, Gerard A. Cangelosi   +9 more
doaj   +1 more source

Comparison Between Cultivation and Sequencing Based Approaches for Microbiota Analysis in Swabs and Biopsies of Chronic Wounds

Frontiers in Medicine, 2021
Chronic wounds are a prominent health concern affecting 0.2% of individuals in the Western population. Microbial colonization and the consequent infection contribute significantly to the healing process.
Aleksander Mahnic, Vesna Breznik, Maja Bombek Ihan, Maja Rupnik, Maja Rupnik   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Elution of Artificial Sputum from Swab by Rotating Magnetic Field-Induced Mechanical Impingement

Applied Sciences, 2017
Cotton-tipped applicator swabs are used as a collection device for many biological samples and its complete elution is a desired step for clinical and forensic diagnostics.
Shubham Banik, James Mahony, P. Ravi Selvaganapathy   +2 more
doaj   +1 more source

New Matrixes to Diagnose Aethina tumida Presence at Apiary Level

Journal of Apicultural Science, 2021
Aethina tumida (Coleoptera: Nitidulidae - Small Hive Beetle - SHB), is a parasite of honey bee colonies that causes the notifiable disease called aethinosis. In 2014, SHB was detected in Southern Italy, where it is still present (Calabria region).
Cersini Antonella, Pietropaoli Marco, Pietrella Gabriele, Rivera-Gomis Jorge, Federico Giovanni, Tofani Silvia, Conti Raffaella, Rubino Roberta C., Di Ruggiero Camilla, Formato Giovanni   +9 more
doaj   +1 more source

A sensitive genetic-based detection capability for Didymosphenia geminata [PDF]

, 2006
It is now well recognized that the increase in global transportation over the last two decades has brought with it an increased potential for the introduction of unwanted microorganisms (aquatic or terrestrial) that may have drastic effects on human and ...
Cary, S. Craig, Coyne, Kathryn J., Crawford, Naomi, Hicks, Brendan J.   +3 more
core   +1 more source

The speciation and genotyping of Cronobacter isolates from hospitalised patients [PDF]

, 2015
The World Health Organization (WHO) has recognised all Cronobacter species as human pathogens. Among premature neonates and immunocompromised infants, these infections can be life-threatening, with clinical presentations of septicaemia, meningitis and ...
[No authors listed], A Baldwin, A. Alsonosi, AB Bowen, BJ Stoll, C Brady, FC Tenover, H Liu, H. Drahovská, H. Kollárová, International Commission on Microbiological Specifications for Foods (ICMSF), J Acker van, J Caubilla-Barron, J. Petrželová, K Tamura, KG Jarvis, KK Lai, M. Kajsík, M. Oriešková, M. Röderová, MA Gosney, ME Patrick, O Holý, O Holý, O. Holý, S Hariri, S Joseph, S Joseph, S Joseph, S Ravisankar, S. Forsythe, S. Hariri, SJ Forsythe, V. Hanulík, Y Sun   +34 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

An Italian Neurorehabilitation Hospital Facing the SARS-CoV-2 Pandemic: Data From 1207 Patients and Workers

Frontiers in Neurology, 2020
Objective: The aim of the present observational study is to report on the data from a large sample of inpatients, clinical staff and other workers at an Italian neurorehabilitation hospital dealing with SARS-CoV-2 infections, in order to analyze how it ...
Antonino Salvia, Giovanni Morone, Marco Iosa, Maria Pia Balice, Stefano Paolucci, Maria Grazia Grasso, Marco Traballesi, Ugo Nocentini, Rita Formisano, Marco Molinari, Angelo Rossini, Carlo Caltagirone   +11 more
doaj   +1 more source